Up till now, every site I've worked on or created has been done with a simple editor and browser. I've also used some packages for my ecommerce forays, like osCommerce and ZenCart. However, this is the first IDE I've used for web development.
My last programming gig was almost six years ago, so picking EW2 up was a bit of a challenge, but nothing too overwhelming. I love the application, but you should be aware that without a bigger monitor, it will be hard to use.